Dr. Francisco Javier Rodríguez Lozano

Biocompatibility and bioactivity of new endodontic materials


  • Bioceramics: definition and applications
  • Regenerative endodontics: the role of dental stem cells  
  • Biocompatibility and bioactivity of calcium silicate based materials
  • Our experimental results with calcium silicate based materials


Calcium silicate-based endodontic materials have been recently introduced and shown to produce appropriate biological responses. These bioactive materials represent a new concept in endodontic treatments and their interaction with dental tissues is considered important. Due to the presence of stem cells in dental tissues, these cells have been used for in vitro studies of biocompatibility with endodontic materials.

Dental stem cells are a multipotent stem cell population that is able to differentiate into both cementoblast cells and odontoblast cells, as in vitro and preclinical studies have previously demonstrated. Their phenotypic characterization has shown them to have high expression levels of the mesenchymal stem cell (MSC) markers, CD105, CD73 and CD90, but not of the hematopoietic markers CD45, CD34, CD14, CD19 and HLA class II.

Further in vitro and in vivo investigations are required to confirm the suitability of these calcium silicate-based endodontic materials for clinical application.

Curriculum Vitae

Dr. Francisco Javier Rodríguez Lozano graduated at the University of Murcia in 2006 and obtained his Ph.D. with honors at the same university in 2009. He is currently staff researcher, and Professor in Dentistry at the University of Murcia.

Dr. Rodríguez is a member of the Spanish  Association of Endodontists (AEDE), and certified member of the European Society of Endodontology (ESE). He published articles in international Journals with particular reference to stem cells and bioceramic materials.

Moreover, Dr. Rodríguez acts as private practioner in his office in Murcia specialising in Endodontics and Operative Dentistry.